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Text File | 1995-12-26 | 1.0 KB | 18 lines | [TEXT/QED1] |
- In order to save 208K on disk space I have removed two matrices used
- to look up values in calculating estimated numbers of synonymous and
- nonsynonymous substitutions. This is an experimental method (!) that
- I haven't tested well. I would love to have some input. These use
- the method of Nei and Gojobori (see: Gojobori, T., E.N. Moriyama, and
- M. Kimura. 1990. Chapt. 33. Statistical methods for estimating
- sequence divergence. Meth. Enzymol. 183: 531-550). If you ever
- anticipate doing these calculations, you can get the matrices
- files from me or generate them yourself. If the files are
- missing from this folder, then you will be prompted to generate
- them when you try to compute substitution numbers. Do this
- some evening just before you go home, since the matrices will
- take several hours to compute. After completion, move the files
- "smatrix" and "nmatrix" into this folder ("Matrices"). Alternatively,
- you can download a self-extracting archive of these files from
- the author's home page:
- <http://biology.fullerton.edu/people/faculty/doug-eernisse>.
-